About

Hi! I'm Santhilal Subhash

Keen to address molecular mechanisms involved in tumorigenesis by integrating datasets from different high- throughput techniques – By analyzing genome-wide chromatin profiles, I have predicted possible mechanisms of active and inactive chromatin-associated RNA molecules – From integrative approach using chromatin and transcriptome datasets of mammalian gametes, developmental stages, somatic, and cancer tissues, I identified a unique set of sperm-specific lincRNAs – In addition to that, using transcriptome and methylome datasets from The Cancer Genome Project (TCGA) PAN-cancer dataset, I have identified cell cycle associated functional RNA molecules having a role as an oncogene and tumor suppressors in multiple cancers – Overall my interest is to integrated transcriptome- and chromatin-based high-throughput datasets to find RNA molecule-based biomarkers in cancer and other diseases that can be used for future therapeutics.

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Contact me here!

Email: santhilal.subhash@ki.se

Phone: +46-(0)8-524 810 66

What i do

Addressing problems in molecular biology using different computational and statistical approaches.

Publications

Checkout a few of my research works

Sperm packaged chromatin and lincRNAs in development and cancer

Sperm-specific developmentally associated lincRNAs using integrative approach

Sperm originated RNA molecules are spotted during stages of human development and activated in multiple cancers. This study gives different perspective on the field of developmental biology and epigenetics.

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Chromatin associated long non-coding RNAs

[Repressive] and [Active] chromatin associated long non-coding RNAs

Characterizing various functional mechanisms of chromatin-associated lncRNAs.

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Cell cycle associated long non-coding RNAs

PAN-cancer analysis

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers.

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Gene enrichment analysis tool

GeneSCF real-time based tool

GeneSCF: a real-time based functional enrichment tool with support for multiple organisms.

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Neuroblastoma associated long non-coding RNs

Characterization of long noncoding RNA transcriptome of neuroblastoma tumors

The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation.

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Other Information

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